An unusual form of lupus erythematosus profundus associated with antiphospholipid syndrome: report of two cases.

© 2013 The Authors. doi: 10.2340/00015555-1528 Journal Compilation © 2013 Acta Dermato-Venereologica. ISSN 0001-5555 Lupus erythematosus profundus (LEP) is a rare clinical feature of cutaneous lupus erythematosus (CLE), characterized by multiple hard subcutaneous induration with panniculitis as the main clinical manifestations of the disease. We describe here two cases of LEP with solitary hard induration extending over a wide area of the back. Both cases showed fibrin thrombosis of the subcutaneous vessels and positive test results for anti-phospholipid antibody. Based on these findings, we thought that the thrombosis associated with antiphospholipid syndrome (APS) was responsible for the peculiar clinical findings in our cases.